Saul J Karpen Selected Research

Alagille Syndrome (Alagille-Watson Syndrome)

1/2022	Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome.
1/2022	Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome.
7/2020	Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome.
1/2019	Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis.
10/2018	Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome.
12/2014	Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia.

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Saul J Karpen Research Topics

Disease

23	Liver Diseases (Liver Disease) 01/2022 - 11/2005
19	Cholestasis 01/2022 - 03/2002
19	Biliary Atresia 09/2020 - 10/2002
13	Inflammation (Inflammations) 09/2020 - 08/2002
8	Non-alcoholic Fatty Liver Disease 01/2022 - 09/2013
8	Fibrosis (Cirrhosis) 09/2020 - 04/2010
6	Alagille Syndrome (Alagille-Watson Syndrome) 01/2022 - 12/2014
5	Pruritus (Itching) 01/2022 - 10/2018
5	End Stage Liver Disease 11/2020 - 03/2006
5	Cardiomyopathies (Cardiomyopathy) 01/2019 - 10/2011
4	Disease Progression 01/2022 - 01/2015
3	progressive familial intrahepatic 1 Cholestasis 01/2022 - 05/2011
3	Neoplasms (Cancer) 05/2010 - 08/2004
2	Fever (Fevers) 01/2022 - 10/2002
2	Acute Liver Failure (Fulminant Hepatic Failure) 11/2021 - 01/2006
2	Portal Hypertension 01/2020 - 01/2018
2	Body Weight (Weight, Body) 01/2020 - 03/2015
2	Intrahepatic Cholestasis 01/2019 - 12/2014
2	Avitaminosis (Vitamin Deficiency) 01/2018 - 12/2014
2	Liver Failure 10/2009 - 11/2006
2	Respiratory Insufficiency (Respiratory Failure) 11/2006 - 10/2006
2	Acute-Phase Reaction 06/2006 - 08/2004
1	Rare Diseases (Rare Disease) 01/2022
1	Cholangitis 12/2020
1	Ascites 12/2020
1	Metabolic Diseases (Metabolic Disease) 10/2020
1	Obesity 10/2020
1	Atherosclerosis 10/2018
1	Steatorrhea 01/2018
1	Diarrhea 01/2018
1	Ciliopathies 01/2018
1	Obstructive Jaundice (Cholestatic Jaundice) 01/2017
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017
1	Bradycardia 01/2017
1	Insulin Resistance 01/2017
1	Cardiomegaly (Heart Hypertrophy) 01/2017
1	Fatty Liver 01/2016
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2015

Drug/Important Bio-Agent (IBA)

23	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 08/2002
11	BilirubinIBA 12/2020 - 03/2002
8	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2013 - 09/2007
5	maralixibatIBA 01/2022 - 10/2018
5	Biomarkers (Surrogate Marker)IBA 01/2022 - 12/2014
5	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2018 - 10/2006
5	LigandsIBA 08/2013 - 08/2005
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 11/2020 - 11/2008
4	LipidsIBA 03/2015 - 09/2007
3	Alanine Transaminase (SGPT)IBA 01/2022 - 09/2014
3	AlbuminsIBA 12/2020 - 09/2014
3	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 11/2020 - 09/2014
3	bile acid binding proteinsIBA 09/2020 - 08/2002
3	Intravenous Immunoglobulins (IVIG)FDA Link 05/2019 - 10/2009
3	SteroidsIBA 11/2018 - 05/2014
3	CytokinesIBA 06/2006 - 08/2002
2	odevixibatIBA 01/2022 - 09/2020
2	Pharmaceutical PreparationsIBA 01/2022 - 01/2008
2	sodium-bile acid cotransporterIBA 01/2020 - 01/2017
2	1- (4- (4- (3,3- dibutyl- 7- (dimethylamino)- 2,3,4,5- tetrahydro- 4- hydroxy- 1,1- dioxido- 1- benzothiepin- 5- yl)phenoxy)butyl)- 4- aza- 1- azoniabicyclo(2.2.2)octaneIBA 01/2020 - 01/2016
2	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2012
2	EnzymesIBA 12/2016 - 01/2008
2	RNA (Ribonucleic Acid)IBA 07/2016 - 06/2010
2	CholesterolIBA 01/2016 - 03/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 09/2013
2	VitaminsIBA 12/2014 - 09/2012
2	StigmasterolIBA 10/2013 - 09/2007
2	Phytosterols (Plant Sterols)IBA 10/2013 - 09/2007
2	Retinoid X Receptors (Retinoid X Receptor)IBA 08/2013 - 02/2012
2	Phosphotransferases (Kinase)IBA 06/2010 - 11/2009
2	CurcuminIBA 04/2010 - 08/2002
2	Retinoid X Receptor alphaIBA 11/2009 - 01/2008
2	EndotoxinsIBA 08/2004 - 08/2002
1	Losartan (Cozaar)FDA LinkGeneric 01/2022
1	Dihydrotachysterol (AT 10)IBA 01/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2020
1	AntipruriticsIBA 07/2020
1	Choline (Choline Chloride)IBA 01/2020
1	CDAA (Randox)IBA 01/2020
1	Amino Acids FDA Link 01/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 05/2019
1	HLA-DR Antigens (HLA-DR)IBA 05/2019
1	CatecholaminesIBA 10/2018
1	Cholic AcidIBA 10/2018
1	AcidsIBA 10/2018
1	Primary Bile Acid MalabsorptionIBA 01/2018
1	CollagenIBA 01/2018
1	Transaminases (Aminotransferases)IBA 12/2016
1	Cysteamine (Mercaptamine)FDA Link 12/2016
1	SodiumIBA 01/2016
1	LeptinIBA 03/2015
1	Interleukin-6 (Interleukin 6)IBA 03/2015
1	EmulsionsIBA 10/2013

Therapy/Procedure

18	Liver Transplantation 11/2021 - 10/2002
13	Therapeutics 01/2022 - 10/2006
7	Hepatic Portoenterostomy 05/2019 - 05/2014
6	Transplantation 08/2013 - 11/2005
5	Parenteral Nutrition 01/2017 - 11/2006
2	Drug Therapy (Chemotherapy) 01/2022 - 11/2008
2	Hepatectomy 11/2008 - 08/2002
1	Analgesia 04/2014